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Abnormal hypermyelination in a neonate with Sturge‐Weber syndrome demonstrated on diffusion‐tensor imaging
Author(s) -
Moritani Toshio,
Kim Jinsuh,
Sato Yutaka,
Bonthius Daniel,
Smoker Wendy R.K.
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21248
Subject(s) - sturge–weber syndrome , diffusion mri , fractional anisotropy , white matter , medicine , magnetic resonance imaging , radiology , pathology , surgery
In Sturge‐Weber syndrome in neonates, evaluation of the extent of the brain parenchymal involvement is difficult due to the lack of calcification, although it is important for initiation of preventive antiepileptic treatment and prediction of prognosis. We present the first application of diffusion‐tensor imaging with fractional anisotropy and ADC maps in a 7‐day‐old neonate. Abnormal T2 hypointensity in the subcortical white matter corresponded to the areas of increased FA and decreased ADC on diffusion‐tensor imaging, which probably represents abnormal hypermyelination. Diffusion‐tensor imaging enabled to quantify the abnormal hypermyelination, and is useful in early diagnosis of Sturge‐Weber syndrome. J. Magn. Reson. Imaging 2008. © 2008 Wiley‐Liss, Inc.