Premium
Accuracy of T1 measurement with 3‐D Look‐Locker technique for dGEMRIC
Author(s) -
Li Wei,
Scheidegger Rachel,
Wu Ying,
Vu Anthony,
Prasad Pottumarthi V.
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21244
Subject(s) - sagittal plane , nuclear medicine , medicine , fast spin echo , articular cartilage , repeatability , osteoarthritis , magnetic resonance imaging , radiology , mathematics , pathology , statistics , alternative medicine
Purpose To validate the accuracy of T1 measurement by three‐dimensional Look‐Locker method (3D LL) for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) of human subjects with and without osteoarthritis (OA), as compared with two‐dimensional inversion recovery fast spin‐echo (2D IR‐FSE) technique. Materials and Methods MR sagittal images of the knees were acquired for T1 mapping in 29 subjects with standard 2D IR‐FSE and 3D LL sequences 90–135 min following administration of 0.2 mmol/kg Gd‐DTPA 2− . T1 maps of femoral and tibial cartilage were generated using custom software. Comparisons in T1 values between the two techniques were performed using regression analysis. Results Good agreement in T1 values between 2D IR‐FSE and 3D LL was observed ( R values of 0.90, and 0.85, and 0.86 for all, OA, and control subjects, respectively) when acquired within 15 min. Conclusion The 3D LL sequence provides accurate T1 estimates of articular cartilage with advantages of entire joint coverage, shorter acquisition time, and a wide range of inversion times sampled within a single acquisition. J. Magn. Reson. Imaging 2008. © 2008 Wiley‐Liss, Inc.