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Age‐related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues
Author(s) -
Tamada Tsutomu,
Sone Teruki,
Toshimitsu Shinya,
Imai Shigeki,
Jo Yoshimasa,
Yoshida Koji,
Yamamoto Akira,
Yamashita Takenori,
Egashira Naoto,
Nagai Kiyohisa,
Fukunaga Masao
Publication year - 2008
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21117
Subject(s) - effective diffusion coefficient , prostate cancer , medicine , prostate , nuclear medicine , diffusion mri , magnetic resonance imaging , diffusion imaging , nuclear magnetic resonance , radiology , cancer , physics
Abstract Purpose To identify age‐related changes and differences in the diffusion of water molecules within the prostate, through diffusion‐weighted imaging (DWI) of the prostate gland in healthy adult Japanese men. Materials and Methods A total of 114 healthy male volunteers (mean age, 55 years; range, 24–81 years) underwent DWI of the prostate with a single‐shot echo‐planar imaging (EPI) sequence using b‐factors of 0 and 1000 seconds/mm 2 . Apparent diffusion coefficient (ADC) values of six locations in the peripheral zone (PZ) and two locations in the central gland (CG) were measured and correlations between region and age were examined. Results ADC values measured within both PZ and CG regions of the prostate showed a uniform distribution, and no significant differences were found between evaluated regions. However, mean ADC values were 1.64 ± 0.27 ×10 −3 mm 2 /second for PZ and 1.26 ± 0.12 ×10 −3 mm 2 /second for CG, representing a significant difference. In addition, significant positive correlations were identified between ADC values for both PZ and CG regions and subject age (r = 0.526, P < 0.0001; r = 0.190, P = 0.0431, respectively). Conclusion ADC values within both PZ and CG regions of the prostate increase with age, and this must be taken into consideration when using DWI in the diagnosis of prostate cancer. J. Magn. Reson. Imaging 2008. © 2008 Wiley‐Liss, Inc.