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Quantification of physiological and hemodynamic indices using T 1 dynamic contrast‐enhanced MRI in intracranial mass lesions
Author(s) -
Singh Anup,
Haris Mohammad,
Rathore Divya,
Purwar Ankur,
Sarma Manoj,
Bayu Getaneh,
Husain Nuzhat,
Rathore Ram K. Singh,
Gupta Rakesh K.
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21080
Subject(s) - hemodynamics , perfusion , nuclear medicine , white matter , voxel , perfusion scanning , contrast (vision) , computation , medicine , mathematics , magnetic resonance imaging , computer science , radiology , algorithm , cardiology , artificial intelligence
Purpose To estimate precontrast tissue parameter ( T 10 ) using fast spin echo (FSE) and to quantify physiological and hemodynamic parameters with leakage correction using T 1 ‐weighted dynamic contrast‐enhanced (DCE) perfusion imaging. Materials and Methods Voxel‐wise T 10 computation was performed followed by the analysis of T 1 ‐weighted DCE perfusion data for the conversion of signal intensity time curve to concentration time curve, estimation of hemodynamic and physiological perfusion indices, and a method for leakage correction. Validations of accuracy of the computations have also been carried out. Results The computed T 10 and hemodynamic perfusion indices in normal white and gray matter were in good agreement with the literature values. Physiological perfusion indices in these regions were found negligible, validating computations. Cerebral blood volume (CBV) values change negligibly over the length of concentration time curve in white matter, gray matter, and lesion (CBV corrected ), while CBV uncorrected (lesion) shows linear increase over time. Conclusion T 1 ‐weighted DCE perfusion data along with FSE‐based T 1 estimation can be used for an accurate estimation of hemodynamic and physiological perfusion indices. J. Magn. Reson. Imaging 2007;26:871–880. © 2007 Wiley‐Liss, Inc.