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Evaluation of a resistance‐based model for the quantification of pulmonary arterial hypertension using MR flow measurements
Author(s) -
Abolmaali Nasreddin,
Seitz Uwe,
Esmaeili Anoosh,
Kock Martin,
Radeloff Daniel,
Ackermann Hanns,
Vogl Thomas J.
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21059
Subject(s) - medicine , pulmonary artery , vascular resistance , cardiology , magnetic resonance imaging , pulmonary hypertension , mean difference , nuclear medicine , blood pressure , radiology , confidence interval
Purpose To establish an estimate for the mean pulmonary arterial pressure (mPAP) derived from noninvasive data acquired with magnetic resonance (MR) velocity‐encoded sequences. Materials and Methods In seven sedated pigs synchronous catheter‐based invasive pressure measurements (IPM) and noninvasive MR were acquired in the main pulmonary artery (MPA) at different severities of pulmonary arterial hypertension (PAH) that were caused by infusion of thromboxane A2 (TxA2). The invasively measured mPAP was correlated with the noninvasive MR velocity data and linear combination equations (LCE) were computed. Results Intravenously applied TxA2 induced a dose dependent level of severity of PAH with an mPAP of up to 54 mmHg without systemic effects. The acceleration time (AT) measured with MR demonstrated the best correlation with the mPAP (r 2 = 0.75). The LCE with the highest correlation (R = 0.945, α < 0.01) between IPM and MR revealed a mean difference of 0, a SD of s = 4.66 and a maximal difference of 12.2 mmHg using the Bland‐Altman analysis. Conclusion Applying the identified LCE allowed the estimation of the mPAP in an acute and resistance‐based model of PAH with high accuracy using noninvasive MR velocity‐encoded sequences. J. Magn. Reson. Imaging 2007;26:646–653. © 2007 Wiley‐Liss, Inc.