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Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractography
Author(s) -
Gaige Terry A.,
Benner Thomas,
Wang Ruopeng,
Wedeen Van J.,
Gilbert Richard J.
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21022
Subject(s) - tractography , diffusion mri , voxel , tongue , anatomy , nuclear magnetic resonance , computer science , magnetic resonance imaging , physics , medicine , artificial intelligence , radiology , pathology
Purpose To study the anatomical relationships involving the intrinsic and extrinsic myofiber populations of the human tongue employing diffusion tensor imaging (DTI) with tractography. Materials and Methods Images of the human tongue in vivo were obtained using a twice‐refocused spin echo DTI pulse sequence at 1.5T, isotropic 3 × 3 × 3 mm 3 voxels, b ‐value 500 seconds/mm 2 , and 90 different diffusion sensitizing gradient directions. Multivoxel tracts were generated along the vectors, corresponding to the directions of maximal diffusion in each voxel. The data was visualized using custom fiber tracking software and images compared with known anatomy. Results DTI tractography depicts the complete three‐dimensional (3D) myoarchitecture of the human tongue, specifically demonstrating the geometric relationships between the intrinsic and extrinsic myofiber populations. These results define the manner in which key extrinsic fiber populations merge with the longitudinally‐, transversely‐, and vertically‐aligned intrinsic fibers. Conclusion The current results display for the first time the use of DTI tractography in vivo to visualize the complete structural anatomy of the human tongue and allow us to consider fundamental structure‐function relationships. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.