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T 1 and T 2 measurements of the fine structures of the in vivo and enucleated human eye
Author(s) -
Patz Samuel,
Bert Robert J.,
Frederick Eric,
Freddo Thomas F.
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21017
Subject(s) - in vivo , extraocular muscles , human eye , ciliary body , physics , nuclear medicine , anatomy , nuclear magnetic resonance , mathematics , medicine , ophthalmology , optics , biology , microbiology and biotechnology
Purpose To measure T 1 and T 2 of the fine structures of the in vivo eye. Materials and Methods Involuntary saccades make it difficult to obtain artifact‐free images. Using a method recently reported (Bert et al, Acad Radiol 2006;12:368–378), near artifact‐free spin‐echo images were obtained. Both an isolated enucleated eye and eight human subjects were studied at 1.5T. Spin‐echo variable TR / TE data was acquired for T 1 / T 2 determination. Average relaxation times were calculated two ways. First, an arithmetic average over different subjects was computed. Second, all data was normalized using the fitted amplitudes of each data set and pooled to obtain a single least squares fit. Results In vivo T 1 / T 2 (msec) are: arithmetic average T 1 , T 2 , normalized data T 1 , T 2 . Anterior chamber: 6233 ± 979, 468 ± 149, 5053 ± 1052, 450 ± 49. Ciliary body: 1916 ± 184, 80 ± 7, 2038 ± 114, 76 ± 3. Chorioretina: 1717 ± 500, 72 ± 25, 1511 ± 230, 78 ± 3. Extraocular muscle: 1581 ± 646, 41 ± 7, 1470 ± 231, 41 ± 1. Iris: 3334 ± 989, 163 ± 63, 3376 ± 338, 153 ± 10. Lens cortex: 1712 ± 466, 93 ± 36, 1413 ± 177, 100 ± 5. Lens nucleus: 1133 ± 40, 26 ± 3, 1138 ± 47, 25 ± 0.4. Optic nerve: 1906 ± 301, 68 ± 16, 1805 ± 244, 71 ± 2. Posterior chamber: 7915 ± 4897, 241 ± 14, 3323 ± 2154, 251 ± 38. Vitreous humor: 5768 ± 1190, 756 ± 804, 4855 ± 1846, 390 ± 8. Conclusion In vivo T 1 and T 2 for many of the fine structures of the human eye have been measured. J. Magn. Reson. Imaging 2007;26:510–518. © 2007 Wiley‐Liss, Inc.