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Proton MR spectroscopic imaging of the medulla and cervical spinal cord
Author(s) -
Edden Richard A.E.,
Bonekamp David,
Smith Mari A.,
Dubey Prachi,
Barker Peter B.
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.21008
Subject(s) - spinal cord , nuclear medicine , cervical spine , nuclear magnetic resonance , medulla , voxel , creatine , medicine , magnetic resonance spectroscopic imaging , magnetic resonance imaging , radiology , anatomy , physics , surgery , psychiatry
Purpose To demonstrate the feasibility of quantitative, one‐dimensional proton MR spectroscopic imaging (1D‐MRSI) of the upper cervical spine and medulla at 3.0 Tesla. Materials and Methods A method was developed for 1D‐point‐resolved spectroscopy sequence (PRESS)‐MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results High‐resolution 1D‐MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N‐acetyl aspartate were estimated to be 2.8 ± 0.5, 8.8 ± 1.8, and 10.9 ± 2.7 mM, respectively, while in the medulla they were 2.6 ± 0.5, 9.1 ± 1.7, and 10.8 ± 0.9 mM. Conclusion Quantitative 1D‐MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla. J. Magn. Reson. Imaging 2007;26:1101–1105. © 2007 Wiley‐Liss, Inc.