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Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus
Author(s) -
Miyati Tosiaki,
Mase Mitsuhito,
Kasai Harumasa,
Hara Masaki,
Yamada Kazuo,
Shibamoto Yuta,
Soellinger Michaela,
Baltes Christof,
Luechinger Roger
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20999
Subject(s) - cerebrospinal fluid , medicine , normal pressure hydrocephalus , magnetic resonance imaging , hydrocephalus , intracranial pressure , asymptomatic , atrophy , compliance (psychology) , cerebrospinal fluid pressure , cardiology , cerebral atrophy , cerebral blood flow , nuclear medicine , radiology , dementia , social psychology , psychology , disease
Abstract Purpose To assess the state and dynamics of the intracranial system in idiopathic normal‐pressure hydrocephalus (I‐NPH), we determined intracranial compliance using magnetic resonance imaging (MRI). Materials and Methods The intracranial compliance index (ICCI), which was defined as the ratio of the peak‐to‐peak intracranial volume change (ICVC p‐p ) to the peak‐to‐peak cerebrospinal fluid (CSF) pressure gradient (PG p‐p ) during the cardiac cycle, was obtained from the net transcranial blood and CSF flow measured with phase‐contrast (PC) cine MRI. ICCI was determined in patients with I‐NPH ( N = 7), brain atrophy, or asymptomatic ventricular dilation (VD) ( N = 6), and in healthy volunteers (control group; N = 11). The changes in ICCI indices were also analyzed after a CSF tap test ( N = 2). Results The ICCI in the I‐NPH group was significantly lower than in the control and VD groups, whereas no difference was found between the control and VD groups. The ICVC p‐p was also lower than in the control and VD groups. However, no significant difference was found in the PG p‐p between groups. The ICCI increased after the tap test. Conclusion Intracranial compliance analysis with MRI makes it possible to noninvasively obtain more detailed information of intracranial biomechanics in the I‐NPH and to assist in the diagnosis of I‐NPH. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.