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Assessment of myocardial oxygen extraction fraction and perfusion reserve with BOLD imaging in a canine model with coronary artery stenosis
Author(s) -
Zhang Haosen,
Gropler Robert J.,
Li Debiao,
Zheng Jie
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20964
Subject(s) - medicine , stenosis , perfusion , dipyridamole , cardiology , reactive hyperemia , artery , blood flow , nuclear medicine
Purpose To determine the feasibility of T 2 ‐weighted BOLD imaging for estimating regional myocardial oxygen extraction fraction (OEF) and approximating perfusion reserve (MPR) simultaneously in a canine model with moderate coronary artery stenosis. Materials and Methods Eight mongrel dogs with moderate coronary artery stenosis underwent BOLD imaging at rest and during dipyridamole‐induced hyperemia, using a turbo spin echo (TSE) sequence. Based on a two‐compartment model, myocardial OEF hyperemia was calculated with the corresponding T 2 . MPR could be approximated based on Fick's law. Results During responsive hyperemia, a regional hypointensity was observed in the abnormally perfused myocardium, reflecting a relatively smaller myocardial T 2 increase (3.06% ± 2.74%, in contrast to 10.19% ± 4.12% in the normal region). The average OEFs in the normally and abnormally perfused myocardial territories were 0.21 ± 0.11 and 0.43 ± 0.12, respectively. For the MPR approximated from the BOLD imaging, a strong correlation (R = 0.9) in the normal myocardium and a good correlation (R = 0.6) distal to the stenosis were obtained compared to microsphere results. Conclusion In a canine model with moderate coronary artery stenosis, TSE‐based BOLD imaging can quantitatively estimate the regional OEF hyperemia and approximate the MPR, and can distinguish segments perfused by defected coronary artery. J. Magn. Reson. Imaging 2007;26:72–79. © 2007 Wiley‐Liss, Inc.