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Soft‐tissue tumors evaluated by line‐scan diffusion‐weighted imaging: Influence of myxoid matrix on the apparent diffusion coefficient
Author(s) -
Maeda Masayuki,
Matsumine Akihiko,
Kato Hiroya,
Kusuzaki Katsuyuki,
Maier Stephan E.,
Uchida Atsumasa,
Takeda Kan
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20931
Subject(s) - soft tissue , medicine , effective diffusion coefficient , pathology , diffusion mri , magnetic resonance imaging , nuclear medicine , radiology
Purpose To compare the apparent diffusion coefficients (ADCs) of myxoid and nonmyxoid soft‐tissue tumors using line‐scan diffusion‐weighted imaging (LSDWI), and to investigate the myxoid matrix influence on ADCs of soft‐tissue tumors. Materials and Methods This study enrolled 44 patients with soft tissue tumors. They were divided into two groups: one with myxoid‐containing soft‐tissue tumors ( N = 23) and the other with nonmyxoid soft‐tissue tumors ( N = 21). The 44 patients were also classified histologically into 26 with malignant soft‐tissue tumors and 18 with benign soft‐tissue tumors. LSDWI was performed using b values of 5 and 1000 second/mm 2 . The ADCs of the tumors were calculated and compared for myxoid and nonmyxoid tumors and for benign and malignant tumors. Results The ADC (mean ± SD) was 1.92 ± 0.41 × 10 –3 mm 2 /second in myxoid containing tumors, whereas the ADC was 0.97 ± 0.33 × 10 –3 mm 2 /second in nonmyxoid tumors. The ADCs of the myxoid and nonmyxoid tumors were significantly different ( P < 0.01). The ADCs were 1.45 ± 0.59 × 10 –3 mm 2 /second in malignant tumors and 1.50 ± 0.64 × 10 –3 mm 2 /second in benign tumors. The ADCs of benign and malignant soft‐tissue tumors were not significantly different. Conclusion The ADCs of myxoid‐containing soft‐tissue tumors were significantly higher than those of nonmyxoid soft‐tissue tumors. The myxoid matrix influences ADCs of both benign and malignant soft‐tissue tumors. J. Magn. Reson. Imaging 2007;25:1199–1204. © 2007 Wiley‐Liss, Inc.