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Assessment of bolus injection protocol with appropriate concentration for quantitative assessment of pulmonary perfusion by dynamic contrast‐enhanced MR imaging
Author(s) -
Ohno Yoshiharu,
Murase Kenya,
Higashino Takanori,
Nogami Munenobu,
Koyama Hisanobu,
Takenaka Daisuke,
Kawamitu Hideaki,
Matsumoto Sumiaki,
Hatabu Hiroto,
Sugimura Kazuro
Publication year - 2007
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20790
Subject(s) - perfusion , medicine , dynamic contrast , nuclear medicine , bolus (digestion) , perfusion scanning , dynamic imaging , dynamic contrast enhanced mri , radiology , magnetic resonance imaging , digital image processing , artificial intelligence , computer science , image (mathematics) , image processing
Purpose To determine the appropriate concentration for quantitative assessment of dynamic contrast‐enhanced pulmonary MR imaging. Materials and Methods A total of 40 consecutive patients with small bronchioalveolar carcinoma underwent perfusion single‐photon emission tomography (SPECT) and three‐dimensional (3D) dynamic MR imaging with a 3D radiofrequency spoiled gradient‐echo sequence. In each patient, 5 mL of contrast media with 0.1, 0.3, and 0.5 mmol/mL were administered at a rate of 5 mL/second. All patients were divided into two groups (<70 kg and ≥70 kg) for assessment of appropriate concentration to quantitatively assess regional perfusion parameter in routine clinical practice. Pulmonary blood flow (PBF) in each protocol was calculated from a signal intensity (SI)–time course curve. Differences and limits of agreement of PBF between dynamic MR imaging (PBF MR ) using three different concentrations and perfusion SPECT (PBF SPECT ) were statistically compared in both patient groups. Results PBF MR using 0.3 mmol/mL in the <70‐kg group and 0.5 mmol/mL in the ≥70‐kg group showed no significant difference compared with PBF SPECT ( P > 0.05). Limits of agreements in 0.3 mmol/mL in the <70‐kg group and 0.5 mmol/mL in the ≥70‐kg group were smaller than those of the other concentrations and small enough for clinical purposes. Conclusion Appropriate concentrations provide accurate and reproducible assessments of regional pulmonary perfusion parameters on 3D dynamic MR perfusion imaging. We suggest using 5 mL of contrast media with 0.3 mmol/mL for patients weighing less than 70 kg and 0.5 mmol/mL for patients weighing 70 kg or more. J. Magn. Reson. Imaging 2007. © 2006 Wiley‐Liss, Inc.