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Inter‐ and intraobserver variability in the evaluation of dynamic breast cancer MRI
Author(s) -
Beresford Mark J.,
Padhani Anwar R.,
Taylor N. Jane,
AhSee MeiLin,
Stirling J. James,
Makris Andreas,
d'Arcy James A.,
Collins David J.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20768
Subject(s) - breast cancer , medicine , region of interest , nuclear medicine , magnetic resonance imaging , mathematics , radiology , cancer
Purpose To quantify variations within and between observers ascribable to manual region of interest (ROI) placement in patients with breast cancer undergoing dynamic MRI. Materials and Methods Expert and nonexpert observers independently outlined tumor ROIs on 30 dynamic T 1 ‐weighted ( T 1 W) MRI scans on five occasions over two months. Lesion size (number of pixels) and kinetic parameter estimates, including the transfer constant (K trans ), were calculated for each ROI placement. Inter‐ and intraobserver variability was assessed with respect to the interval between drawings, lesion morphology, and observer experience. Results For the nonexpert, the variability reduced with decreasing time intervals between ROI drawings (the coefficient of variance (wCV) values at two months, two weeks, one day, and same‐day time intervals were respectively 11.6%, 10.7%, 4.8%, and 2.6% for lesion size, and 8.9%, 9.7%, 6.7%, and 3.2% for K trans ). For the expert observer, the variability was smaller overall and more constant, but improved for same‐day ROI placements (region size wCV: 7.5%, 6.2%, 7.1%, and 3.7%; K trans wCV: 5.4%, 5.3%, 5.6%, and 4.5%). Conclusion Significant observer variability in manual ROI placement occurs in dynamic MRI of breast cancer. For serial patient studies, ROI placements should be outlined at the same sitting to minimize observer error. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.