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Magnetic resonance investigation of bone marrow following priming and stem cell mobilization
Author(s) -
Chabanova E.,
Johnsen H.E.,
Knudsen L. Meldgaard,
Larsen L.,
Løgager V.,
Yingru S.,
Thomsen H.S.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20760
Subject(s) - bone marrow , stem cell , medicine , haematopoiesis , magnetic resonance imaging , granulocyte colony stimulating factor , priming (agriculture) , multiple myeloma , cyclophosphamide , nuclear medicine , pathology , chemotherapy , biology , radiology , germination , botany , genetics
Purpose To evaluate application of MRI and magnetic resonance spectroscopy (MRS) to monitor bone marrow cellularity during pretransplant priming with chemotherapy and hematopoietic growth factor (HGF) administration. Materials and Methods A total of 10 lymphoma and myeloma patients, in remission following induction therapy and considered eligible for high‐dose therapy and autologous stem cell transplantation, were included in the study. MR investigation was scheduled four times: at study entry, and one, two, and four weeks following priming. Priming with cyclophosphamide and recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) started the day after study entry. MR parameters studied in a region of interest were as follows: bone marrow intensity on short‐time inversion‐recovery (STIR) turbo spin‐echo (TSE; thus STIRTSE) and on T1‐weighted TSE (T1TSE) images, T2 value for fat component, T2 value for water component, water/fat ratio (W/F), T1 value for fat component, and T1 value for water component. Results The results did not support the hypothesis that hematopoietic expansion quantitated and monitored by MR correlates to the level of mobilized progenitor cells. Conclusion The results indicate that release of stem cells is a more complex phenomenon than hematopoietic expansion and reduction of fat tissue in bone marrow. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.