Premium
In vivo measurement of plaque burden in a mouse model of Alzheimer's disease
Author(s) -
Borthakur Arijitt,
Gur Tamar,
Wheaton Andrew J.,
Corbo Matthew,
Trojanowski John Q.,
Lee Virginia M.Y.,
Reddy Ravinder
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20751
Subject(s) - in vivo , hippocampus , genetically modified mouse , pathology , relaxometry , senile plaques , amyloid (mycology) , alzheimer's disease , cortex (anatomy) , medicine , neuroscience , disease , transgene , magnetic resonance imaging , chemistry , biology , radiology , biochemistry , microbiology and biotechnology , spin echo , gene
Purpose To demonstrate an MRI method for directly visualizing amyloid‐β (Aβ) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T 1ρ relaxation rate increases progressively with Alzheimer's disease (AD)‐related pathology in the tg mouse brain. Materials and Methods We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T 1ρ via quantitative relaxometric maps. Results A significant decrease in T 1ρ was observed in the cortex and hippocampus of 12‐ and 18‐month‐old animals compared to their age‐matched controls. There was also a correlation between changes in T 1ρ and the age of the animals. Conclusion T 1ρ relaxometry may be a sensitive method for noninvasively determining AD‐related pathology in APP/PS1 mice. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.