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Automated perfusion‐weighted MRI using localized arterial input functions
Author(s) -
Lorenz Cory,
Benner Thomas,
Chen Poe Jou,
Lopez Chloe Joan,
Ay Hakan,
Zhu Ming Wang,
Menezes Nina M.,
Aronen Hannu,
Karonen Jari,
Liu Yawu,
Nuutinen Juho,
Sorensen A. Gregory
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20717
Subject(s) - voxel , cerebral blood flow , receiver operating characteristic , nuclear medicine , computer science , smoothing , mathematics , medicine , algorithm , artificial intelligence , pattern recognition (psychology) , statistics , cardiology
Purpose To investigate the utility of an automated perfusion‐weighted MRI (PWI) method for estimating cerebral blood flow (CBF) based on localized arterial input functions (AIFs) as compared to the standard method of manual global AIF selection, which is prone to deconvolution errors due to the effects of delay and dispersion of the contrast bolus. Materials and Methods Analysis was performed on spin‐ and gradient‐echo EPI images from 36 stroke patients. A local AIF algorithm created an AIF for every voxel in the brain by searching out voxels with the lowest delay and dispersion, and then interpolating and spatially smoothing them for continuity. A generalized linear model (GLM) for predicting tissue outcome, and MTT lesion volumes were used to quantify the performance of the localized AIF method in comparison with global methods using ipsilateral and contralateral AIFs. Results The algorithm found local AIFs in each case without error and generated a higher area under the receiver operating characteristic (ROC) curve compared to both global‐AIF methods. Similarly, the local MTT lesion volumes had the least mean squared error (MSE). Conclusion Automated CBF calculation using local AIFs is feasible and appears to produce more useful CBF maps. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.