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Evaluation of different cerebral mass lesions by perfusion‐weighted MR imaging
Author(s) -
Hakyemez Bahattin,
Erdogan Cuneyt,
Bolca Naile,
Yildirim Nalan,
Gokalp Gokhan,
Parlak Mufit
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20707
Subject(s) - medicine , meningioma , hemangioblastoma , cerebral blood volume , nuclear medicine , glioma , magnetic resonance imaging , schwannoma , differential diagnosis , radiology , pathology , cancer research
Purpose To investigate the contribution of perfusion‐weighted MR imaging (PWI) by using the relative cerebral blood volume (rCBV) ratio in the differential diagnosis of various intracranial space‐occupying lesions. Materials and Methods This study involved 105 patients with lesions (high‐grade glioma ( N = 26), low‐grade glioma ( N = 11), meningioma ( N = 23), metastasis ( N = 25), hemangioblastoma ( N = 6), pyogenic abscess ( N = 4), schwannoma ( N = 5), and lymphoma ( N = 5)). The patients were examined with a T2*‐weighted (T2*W) gradient‐echo single‐shot EPI sequence. The rCBV ratios of the lesions were obtained by dividing the values obtained from the normal white matter. Statistical analysis was performed with the Mann‐Whitney U‐test. A P ‐value less than 0.05 was considered statistically significant. Results The rCBV ratio was 5.76 ± 3.35 in high‐grade gliomas, 1.69 ± 0.51 in low‐grade gliomas, 8.02 ± 3.89 in meningiomas, 5.27 ± 3.22 in metastases, 11.36 ± 4.41 in hemangioblastomas, 0.76 ± 0.12 in abscesses, 1.10 ± 0.32 in lymphomas, and 3.23 ± 0.81 in schwannomas. The rCBV ratios were used to discriminate between 1) high‐ and low‐grade gliomas ( P < 0.001), 2) hemangioblastomas and metastases ( P < 0.05), 3) abscesses from high‐grade gliomas and metastases ( P < 0.001), 4) schwannomas and meningiomas ( P < 0.001), 5) lymphomas from high‐grade gliomas and metastases ( P < 0.001), and 6) typical meningiomas and atypical meningiomas ( P < 0.01). Conclusion rCBV ratios can help discriminate intracranial space‐occupying lesions by demonstrating lesion vascularity. It is possible to discriminate between 1) high‐ and low‐grade gliomas, 2) hemangioblastomas and other intracranial posterior fossa masses, 3) abscesses from high‐grade gliomas and metastases, 4) schwannomas and meningiomas, 5) lymphomas and high‐grade gliomas and metastases, and 6) typical and atypical meningiomas. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.