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Significance of the perfusion‐diffusion mismatch in chronic cerebral ischemia
Author(s) -
Surikova Irina,
Meisel Stefanie,
Siebler Mario,
Wittsack HansJörg,
Seitz Rüdiger J.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20686
Subject(s) - medicine , perfusion , ischemia , magnetic resonance imaging , cerebral blood flow , infarction , stroke (engine) , middle cerebral artery , perfusion scanning , cerebral infarction , cardiology , magnetic resonance angiography , diffusion mri , lesion , blood volume , brain ischemia , radiology , pathology , myocardial infarction , mechanical engineering , engineering
Purpose To determine whether the perfusion deficit could predict brain infarction in patients with chronic cerebral ischemia who experienced recurring episodes of neurological symptoms and showed a perfusion‐diffusion mismatch on magnetic resonance (MR) images. Materials and Methods In 53 consecutive patients (38 males and 15 females, 62 ± 13 years old) with ischemia in the middle cerebral artery (MCA) territory, lesion volumetry was performed on parametric maps of the time‐to‐peak, the cerebral blood volume, and diffusion‐weighted (DW) images. The infarct lesions were assessed on follow‐up T2‐weighted (T2W) MR images after eight days. Cerebrovascular changes were determined by time‐of‐flight (TOF) MR angiography (MRA). Inferential and correlation statistics were used. Results Patients with chronic ischemic brain disease ( N = 39) who presented with a severe perfusion‐diffusion mismatch in the presence of a normal cerebral blood volume had no or small brain infarctions as found on follow‐up T2W images. MRA revealed widespread abnormalities of the basal cerebral arteries compatible with brain perfusion abnormalities. In contrast, in acute stroke patients ( N = 14) the deficit of cerebral perfusion predicted the infarct lesion in the T2W images. Conclusion Our results suggest that in chronic cerebral ischemia the normal blood volume was maintained despite the depression of cerebral perfusion and recurring minor insults. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.