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In vivo R1‐enhancement mapping of canine myocardium using ceMRI with Gd(ABE‐DTTA) in an acute ischemia‐reperfusion model
Author(s) -
Kiss P.,
Suranyi P.,
Simor T.,
SaabIsmail N.H.,
Elgavish A.,
Hejjel L.,
Elgavish G.A.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20661
Subject(s) - perfusion , ischemia , in vivo , myocardial ischemia , medicine , thickening , nuclear medicine , correlation , cardiology , chemistry , mathematics , geometry , biology , microbiology and biotechnology , polymer science
Purpose To demonstrate the usefulness of normalized ΔR1 (ΔR1 n ) mapping in myocardial tissue following the administration of the contrast agent (CA) Gd(ABE‐DTTA). Materials and Methods Ischemia‐reperfusion experiments were carried out in 11 dogs. The method exploited the relatively long tissue lifetime of Gd(ABE‐DTTA), and thus no fast R1 measurement technique was needed. Myocardial perfusion was determined with colored microspheres (MP). Results With varying extent of ischemia, impaired wall motion (WM) and lower ΔR1 n values were detected in the ischemic sectors, as opposed to the nonischemic sectors where normal WM and higher ΔR1 n were observed. Based on the ΔR1 n , data from the myocardial perfusion assay and the ΔR1 n maps were compared in the ischemic sectors. A correlation analysis of these two parameters demonstrated a significant correlation (R = 0.694, P < 0.005), validating the ΔR1 n ‐mapping method for the quantitation of ischemia. Similarly, pairwise correlations were found for the MP, ΔR1 n , and wall thickening (WT) values in the same areas. Based on the correlation between ΔR1 n and MP, ΔR1 n maps calculated with a pixel‐by‐pixel resolution can be converted to similarly high‐resolution myocardial perfusion maps. Conclusion These results suggest that the extent of the severity of ischemia can be quantitatively represented by ΔR1 n maps obtained in the presence of our CA. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.