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MRI, volumetry, 1 H spectroscopy, and cerebropetal blood flowmetry in childhood idiopathic anatomic megalencephaly
Author(s) -
Koudijs Suzanne M.,
van der Grond Jeroen,
Hoogendoorn Mechteld L.C.,
Hulshoff Pol Hilleke E.,
Schnack Hugo G.,
Witkamp Theo D.,
Gooskens Rob H.J.M.,
van Nieuwenhuizen Onno,
Braun Kees P.J.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20628
Subject(s) - medicine , ventriculomegaly , choline , in vivo magnetic resonance spectroscopy , hydrocephalus , cerebrospinal fluid , brain size , magnetic resonance imaging , nuclear medicine , megalencephaly , cerebral blood volume , creatine , pathology , radiology , pregnancy , fetus , genetics , biology
Purpose To evaluate cerebral abnormalities in childhood idiopathic anatomic megalencephaly (MC) by means of different magnetic resonance (MR) modalities. Materials and Methods MRI, volumetry, spectroscopy, and cerebropetal blood flowmetry were performed in six children with idiopathic anatomic MC, and seven volunteers. Results MRI revealed an increased ventricular system in five of six patients. A thalamic hamartoma was found in one patient and a Chiari I malformation was found in two. Volumetric analysis showed a disproportional increase of ventricular volume but normal subarachnoid cerebrospinal fluid (CSF) volume. Supratentorial volume was disproportionally increased compared to cerebellar volume. Intracranial volume correlated significantly with skull circumference. MR spectroscopy (MRS) N ‐acetyl aspartate/choline (NAA/Cho) peak ratios in WM were significantly higher in patients than in controls. Choline/creatine (Cho/Cr) peak ratios in WM were significantly lower in patients. Cortical gray matter (GM) MRS ratios were unaltered. Cerebropetal flow was increased in MC, possibly related to increased brain volume. Conclusion This study reveals associated developmental anomalies for idiopathic anatomic MC. A relative ventriculomegaly was found, which should not be misinterpreted as true hydrocephalus. In contrast to metabolic MC, MRS showed no severe disturbances. Total intracranial volume is correlated to skull circumference and cerebropetal blood flow. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.