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Proton and sodium MRI assessment of fluid level in calf tissue
Author(s) -
Zuo Chun S.,
Villafuerte Rosemond A.,
Henry Michael E.,
Butman Michelle,
Dobbins Robert L.,
He Yiwu,
Orban Barbara S.,
Cayetano Kenroy,
Wang Liqun,
Brown Andrew P.,
Nunez Derek J.,
Brown John,
Renshaw Perry F.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20624
Subject(s) - supine position , saline , sodium , extracellular fluid , medicine , magnetic resonance imaging , nuclear medicine , body fluid , chemistry , anatomy , anesthesia , extracellular , radiology , biochemistry , organic chemistry
Purpose To investigate the feasibility of using 1 H and 23 Na MRI to detect fluid levels in the lower leg muscle. Materials and Methods Proton and sodium MRI was applied to detect body fluid levels in the lower leg muscles of 18 healthy young male subjects at 3T and 4T. The paradigms under investigation were a postural change from sitting upright to lying supine, and saline infusion. Results We found that the average proton MR signal in gastrocnemius and soleus muscles were reduced following the postural change by 3.5% ± 1.4% ( P < 0.05) and rose following saline infusion by 3.7% ± 0.9% ( P < 0.01). More dramatically, the sodium MR signal decreased by 7.1% ± 1.2% ( P < 0.01) following the postural change and increased following saline infusion by 12% ± 3.8% ( P < 0.05). The ratio of intra‐ to extracellular fluid levels was 1.6 ± 0.5 for the subjects based on the acquired proton and sodium data. Conclusion Our results indicate that proton and sodium MRI can be used to assess fluid levels in the lower extremities, and this technique may be applied to evaluate fluid retention. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.