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Comparison of the magnetization transfer ratio and fluid‐attenuated inversion recovery imaging signal intensity in differentiation of various cystic intracranial mass lesions and its correlation with biological parameters
Author(s) -
Mishra Asht M.,
Reddy Sangala J.,
Husain Mazhar,
Behari Sanjay,
Husain Nuzhat,
Prasad Kashi N.,
Kumar Sunil,
Gupta Rakesh K.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20621
Subject(s) - fluid attenuated inversion recovery , abscess , medicine , intensity (physics) , nuclear medicine , brain abscess , magnetization transfer , magnetic resonance imaging , cerebrospinal fluid , lesion , pathology , nuclear magnetic resonance , radiology , surgery , physics , quantum mechanics
Purpose To compare the signal intensity on the fluid attenuated inversion recovery (FLAIR) sequence and magnetization transfer ratios (MTRs) for the differentiation of abscesses from non‐abscess cystic brain lesions, and to correlate these MR parameters with the viscosity, viable cell density and total protein concentration of the cystic fluid. Materials and Methods Signal intensity on FLAIR and MTRs from the cystic cavity of lesions were calculated from 33 patients (brain abscess ( N = 12) and non‐abscess ( N = 21)). The fluid from the lesion was aspirated at the time of surgery, and the viscosity, viable cell density, and total protein concentration were measured. Results Signal intensity on FLAIR correlated significantly with the total protein concentration in abscess (r = 0.60, P < 0.05) and non‐abscess lesions (r = 0.41, P < 0.05). However, there was no significant difference ( P > 0.05) in the FLAIR signal intensity of the abscess (318.8 ± 75) and non‐abscess group (258 ± 47). The MTR of the brain abscesses (13 ± 0.95) was significantly higher ( P < 0.05) than that of the non‐abscess group (3.5 ± 0.3). A significant correlation was observed between MTR and viscosity (r = 0.75, P < 0.05), total protein concentration (r = 0.60, P < 0.05), and cell density (r = 0.70, P < 0.05) in brain abscess, and viscosity (r = 0.81, P < 0.05) and total protein concentration (r = 0.41, P < 0.05) in non‐abscess lesions. Conclusion It is possible to differentiate brain abscesses from non‐abscess cystic lesions using MT imaging. The MTR correlates significantly with the viscosity, viable cell density, and total protein concentration in brain abscess, and with viscosity and total protein concentration in non‐abscess lesions. FLAIR signal intensity correlates significantly only with the total protein concentration in abscess and non‐abscess lesions. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.