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Predicting and monitoring response to chemotherapy by 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea in subcutaneously implanted 9L glioma using the apparent diffusion coefficient of water and 23 Na MRI
Author(s) -
Babsky Andriy M.,
Hekmatyar S. K.,
Zhang Hong,
Solomon James L.,
Bansal Navin
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20615
Subject(s) - carmustine , effective diffusion coefficient , nitrosourea , medicine , glioma , nuclear medicine , chemotherapy , magnetic resonance imaging , radiology , cancer research , cyclophosphamide
Abstract Purpose To examine the effects of the alkylating anticancer drug 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU) on 23 Na MRI and the water apparent diffusion coefficient (ADC) in subcutaneously‐ (sc‐) implanted 9L glioma in rats. Materials and Methods 23 Na MRI and 1 H water ADC measurements were performed on sham‐treated control ( N = 6) and BCNU‐treated ( N = 15) Fisher rats one day before BCNU injection and then one, three, and five days after BCNU injection. Results The BCNU‐treated tumors were divided into BCNU‐responsive (R BCNU ) and BCNU‐nonresponsive (NR BCNU ) groups depending on the tumor volume changes that occurred after therapy. The pretreatment 23 Na MRI signal intensity (SI) and water ADC values were higher in R BCNU tumors compared to NR BCNU tumors. 23 Na MRI SI and water ADC increased with tumor growth in control and NR BCNU groups, but these changes were interrupted by BCNU therapy in R BCNU group. Conclusion 23 Na MRI and water ADC measurements may be useful for predicting and monitoring response to chemotherapy in some tumors. However, the changes that occurred in 23 Na MRI SI and water ADC in sc‐implanted 9L tumors are in contrast to previously published results for BCNU therapy of orthotopic 9L tumors. This may have important implications for monitoring therapy response in tumors. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.