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MR‐visible coatings for endovascular device visualization
Author(s) -
Unal Orhan,
Li Junwei,
Cheng Weiguo,
Yu Hyuk,
Strother Charles M.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20555
Subject(s) - magnetic resonance imaging , biomedical engineering , materials science , scanner , visualization , off the shelf , gradient echo , medicine , fast spin echo , radiology , computer science , software engineering , artificial intelligence
Purpose To investigate the potential utility of magnetic resonance (MR)‐visible coatings for passive visualization of therapeutic endovascular devices such as catheters and guidewires. Materials and Methods Using a multistep coating process, gadolinium‐based coatings were applied to commercially available off‐the‐shelf catheters and guidewires. These coated devices were imaged in phantoms made of fat‐free yogurt, saline, and whole blood and also in live canine aorta on a 1.5‐T cardiovascular MR scanner using T1‐weighted two‐dimensional radiofrequency (RF)‐spoiled gradient‐recalled echo, two‐dimensional spin echo, and three‐dimensional RF‐spoiled gradient‐recalled echo techniques. Results Commercially available off‐the shelf catheters (4, 5, and 6 French) and guidewires (0.038 inch) were clearly visualized in all phantoms and canine aorta and the coatings proved to be durable and imageable without degradation in signal intensity up to 24 hours. MR‐visible coatings address some of the shortcomings that have previously limited the role of MR as a guidance tool. Conclusion Both in vitro and in vivo visualization of therapeutic endovascular devices coated with MR‐visible coatings are found to be clinically viable. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.