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Alterations of the proton‐T 2 time in relaxed skeletal muscle induced by passive extremity flexions
Author(s) -
Rump Jens,
Braun Jürgen,
Papazoglou Sebastian,
Taupitz Matthias,
Sack Ingolf
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20534
Subject(s) - biceps , forearm , contraction (grammar) , anatomy , electromyography , medicine , skeletal muscle , muscle contraction , wrist , elbow , nuclear magnetic resonance , physics , physical medicine and rehabilitation
Purpose To demonstrate reciprocal changes of the apparent proton‐T 2 time in the biceps and triceps due to passive contraction and extension of the muscle fibers. Materials and Methods The contraction state of the upper arm muscles of six healthy volunteers was passively changed by alternating the forearm position between the straight‐arm position and an elbow flexion of 90°. The relaxation of the muscle during passive contraction and extension was measured with the use of muscle electromyography (EMG) experiments. Spin‐echo (SE) MRI with increasing echo times (TEs) of 12–90 msec was used to acquire the averaged signal decay of the segmented biceps and triceps. The apparent T 2 was deduced using monoexponential least‐square fitting. Results The median T 2 alterations in biceps and triceps among all volunteers were found to be 1.2 and –1.3 msec in the straight and bent forearm positions, respectively. The confidence intervals (0.5 to 1.7 msec in biceps, and –2.6 to –1.1 msec in triceps) clearly indicate that proton‐T 2 in MR images is significantly ( P < 0.05) prolonged with muscle contraction. Conclusion The observed increase of the proton‐T 2 time was correlated with a passive contraction of skeletal muscle fibers. This passive effect can be attributed to changes in the intracellular water mobility corresponding to the well‐known “active” T 2 increase that occurs after stimulation of muscle. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.