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Pulsed arterial spin labeling parameter optimization for an elderly population
Author(s) -
Campbell Alison M.,
Beaulieu Christian
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20503
Subject(s) - arterial spin labeling , perfusion , cerebral blood flow , transit time , cerebral perfusion pressure , perfusion scanning , medicine , population , signal (programming language) , nuclear medicine , nuclear magnetic resonance , cardiology , biomedical engineering , computer science , physics , environmental health , transport engineering , engineering , programming language
Purpose To optimize pulsed arterial spin labeling (PASL) parameters for the elderly to take into account possible perfusion changes that occur in the brain with age. Materials and Methods Healthy young ( N = 14, age range = 21–27 years) and elderly ( N = 12, age range = 61–67 years) subjects were scanned using Q2TIPS (QUIPSS II with thin‐slice TI, periodic saturation) with varying inversion times (TI 2 ) at 1.5T. The difference signal (ΔM), transit time (δt), and cerebral blood flow (CBF) were calculated in segmented gray matter (GM). Results The young displayed more perfusion‐weighted signal difference than the elderly at all TI 2 's. The peak ΔM occurred at TI 2 ∼ 1300 msec and 1500 msec in the young and elderly groups, respectively. Qualitatively, intravascular signal was minimal in the younger group by TI 2 = 1500 msec, whereas a longer TI 2 of 1800 msec was needed to minimize this signal in the elderly. The transit time was ∼100 msec longer in the elderly, and CBF was in the range of literature values. Conclusion For acquiring perfusion‐weighted images with minimal intravascular signal and adequate tissue signal for PASL studies of cerebral perfusion in the elderly, a longer inversion time is advantageous. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.