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Diffusion‐weighted imaging of normal and malignant prostate tissue at 3.0T
Author(s) -
Pickles Martin D.,
Gibbs Peter,
Sreenivas Muthyala,
Turnbull Lindsay W.
Publication year - 2006
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20477
Subject(s) - effective diffusion coefficient , prostate cancer , medicine , prostate , nuclear medicine , magnetic resonance imaging , diffusion mri , asymptomatic , diffusion imaging , radiology , cancer , pathology
Purpose To measure the apparent diffusion coefficient (ADC) of normal and malignant prostate tissue at 3.0T using a phased‐array coil and parallel imaging, and determine the utility of ADC values in differentiating tumor from normal peripheral zone (PZ). Materials and Methods ADC values were calculated for 49 patients (tumor and PZ) with evidence of prostate cancer. Additionally, for nine asymptomatic volunteers, ADC values were determined for apparently normal central gland and PZ. A single‐shot EPI diffusion‐weighted imaging (DWI) technique with b = 0 and 500 seconds/mm 2 was employed. Results ADC values were significantly lower for tumor (1.38 ± 0.32 × 10 −3 mm 2 /second) than for patient PZ (1.95 ± 0.50 × 10 −3 mm 2 /second, P < 0.001) and volunteer PZ (1.60 ± 0.25 × 10 −3 mm 2 /second, P = 0.031). A considerable overlap of ADC values was noted between patient tissue types. Conclusion DWI of the prostate at 3.0T in conjunction with a phased‐array coil and parallel imaging allows ADC calculation of the prostate. ADC values were lower for tumors compared to normal‐appearing PZ; however, there was considerable intersubject variability. J. Magn. Reson. Imaging 2006. © 2005 Wiley‐Liss, Inc.