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MR‐guided laser irradiation of recurrent glioblastomas
Author(s) -
Schwarzmaier HansJoachim,
Eickmeyer Frank,
von Tempelhoff Wernholt,
Fiedler Volkhard Ulrich,
Niehoff Hendrik,
Ulrich Slif Dagobert,
Ulrich Frank
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20446
Subject(s) - medicine , glioblastoma , magnetic resonance imaging , natural history , radiation therapy , regimen , radiology , nuclear medicine , surgery , cancer research
We treated two patients with recurrent glioblastoma multiforme using Nd:YAG laser irradiation in the framework of a salvage therapy. The underlying concept is to achieve cytoreduction by partial coagulation of the tumor. Magnetic resonance imaging (MRI) follow‐up examinations revealed a volume reduction of the laser‐irradiated areas, while the untreated parts of the tumor exhibited a progression. The survival time after the diagnosis of the recurrence was 16 and 20 months, respectively, which is substantially (about four times) longer than the natural history of the disease would suggest. In conclusion, cytoreduction by laser irradiation may be a promising option for patients suffering from recurrent glioblastoma multiforme. Future work should optimize the therapeutic regimen and evaluate this treatment approach in controlled clinical trials. J. Magn. Reson. Imaging 2005. © 2005 Wiley‐Liss, Inc.