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Dynamic susceptibility contrast perfusion imaging of cerebral ischemia in nonhuman primates: Comparison of Gd‐DTPA and NMS60
Author(s) -
Liu Yutong,
D'Arceuil Helen,
He Julian,
Duggan Mike,
Seri S.,
Hashiguchi Yuji,
Nakatani Akira,
Gonzalez R. Gilberto,
Pryor Johnny,
de Crespigny Alex
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20403
Subject(s) - perfusion , perfusion scanning , medicine , contrast (vision) , gadolinium , nuclear medicine , stroke (engine) , middle cerebral artery , ischemia , magnetic resonance imaging , cerebral perfusion pressure , radiology , cardiology , chemistry , artificial intelligence , computer science , mechanical engineering , organic chemistry , engineering
Purpose To study a new gadolinium (Gd) contrast agent—NMS60—for MR perfusion‐weighted imaging (PWI) of brain tissue. Materials and Methods NMS60 is a Gd 3+ trimer with a molecular weight of 2158 Daltons, and a T 2 relaxivity almost three times higher than that of Gd‐DTPA. Middle cerebral artery (MCA) occlusion was induced in nine nonhuman primates. The animals were scanned acutely and for up to six follow‐up time points. PWI peak, and time‐to‐peak maps were generated, and perfusion deficit volumes were measured from these maps. The values of peak, time‐to‐peak, and perfusion deficit volume were compared between NMS60 and GD‐DTPA. Results These results demonstrate that there was no significant difference in our calculated perfusion parameters between the two contrast agents. Conclusion The two agents were found to be equally effective for PWI for acute and chronic stroke in primates. Along with its previously demonstrated advantage for T 1 ‐enhanced imaging, the current results show that NMS60 is a viable contrast agent for use in stroke patients. J. Magn. Reson. Imaging 2005. © 2005 Wiley‐Liss, Inc.