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Detection of acute renal ischemia in swine using blood oxygen level‐dependent magnetic resonance imaging
Author(s) -
Alford Sara K.,
Sadowski Elizabeth A.,
Unal Orhan,
Polzin Jason A.,
Consigny Daniel W.,
Korosec Frank R.,
Grist Thomas M.
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20389
Subject(s) - coronal plane , medulla , magnetic resonance imaging , cortex (anatomy) , medicine , ischemia , renal cortex , kidney , renal artery , occlusion , anatomy , nuclear medicine , radiology , biology , neuroscience
Purpose To determine the feasibility and sensitivity of blood oxygen level‐dependent (BOLD) magnetic resonance imaging (MRI) to detect acute renal ischemia, using a swine model, and to present the causes of variability and assess techniques that minimize variability introduced during data analysis. Materials and Methods BOLD MRI was performed in axial and coronal planes of the kidneys of five swine. Color R2* maps were calculated and mean R2* values and 95% confidence intervals (CIs) for the cortex and medulla were determined for baseline, renal artery occlusion and reperfusion conditions. Paired Student's t ‐tests were used to determine significance. Results Mean R2* measurements increased from baseline during renal artery occlusion in the cortex (axial, 13.8–24.6 second −1 ; coronal, 14.4–24.7 second −1 ) and medulla (axial, 19.3–32.2 second −1 ; coronal, 20.1–30.7 second −1 ). These differences were significant for both the cortex (axial, P < 0.04; coronal, P < 0.005) and medulla (axial, P < 0.02; coronal, P < 0.0005). No significant change was observed in the contralateral kidney. Conclusion R2* values were significantly higher than baseline for medulla and cortex during renal artery occlusion. More variability exists in R2* measurements in the medulla than the cortex and in the axial than the coronal plane. J. Magn. Reson. Imaging 2005. © 2005 Wiley‐Liss, Inc.