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Microneurography of human median nerve
Author(s) -
Bilgen Mehmet,
Heddings Archie,
AlHafez Baraa,
Hasan Wohaib,
McIff Terence,
Toby Bruce,
Nudo Randolph,
Brooks William M.
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20345
Subject(s) - microneurography , biomedical engineering , diffusion mri , medicine , peripheral , magnetic resonance neurography , peripheral nerve , fractional anisotropy , tractography , magnetic resonance imaging , anatomy , radiology , baroreflex , heart rate , blood pressure
Purpose To examine the possibility of performing high‐resolution MRI (microneurography) on peripheral nerves. Materials and Methods A specific radio frequency (RF) coil was developed to probe the human median nerve at a magnetic field strength of 9.4 T and tested on three excised samples by acquiring microneurograms. Results The microneurograms revealed neuronal tissue constituents at subfascicular level. The contrast features on proton‐density and T1‐ and T2‐weighted images were described and compared. The microscopic water movement was quantified using diffusion weighting parallel and orthogonal to the neuronal fiber orientation. The characteristics of anisotropic diffusion in the median nerve were comparable to those reported from other biological tissues (white matter and kidney). Conclusion The results overall suggest that microneurography might provide new noninvasive insights into microscopic gross anatomy of the peripheral nerve, injury evaluation, and efficacy of repair, although the feasibility at current clinically relevant field strengths is yet to be determined. J. Magn. Reson. Imaging 2005;21:826–830. © 2005 Wiley‐Liss, Inc.