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Gd(ABE‐DTTA)‐enhanced cardiac MRI for the diagnosis of ischemic events in the heart
Author(s) -
Simor Tamás,
Gaszner Balázs,
Oshinski John N.,
Waldrop Sandra M.,
Pettigrew Roderic I.,
Horváth Iván G.,
Hild Gábor,
Elgavish Gabriel A.
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20326
Subject(s) - medicine , ischemia , contrast (vision) , perfusion , myocardial ischemia , nuclear medicine , cardiology , artificial intelligence , computer science
Purpose To demonstrate that contrast‐enhanced MRI (ceMRI) with the aid of Gd(ABE‐DTTA) is able to detect ischemic events in the heart in a canine ischemia/reperfusion (30/40 minutes) model. Materials and Methods ECG‐gated, T1‐weighted MR image sets (four to five slices each) with three‐minute time resolution were collected in transiently LAD‐occluded dogs. Following the acquisition of control image sets, ischemia was started by occluding the LAD. Either Gd(ABE‐DTTA) ( N = 6) or Gd(DTPA) ( N = 6) was injected, and imaging was continued for 30 minutes of ischemia and 40 minutes of reperfusion. The contrast agent (CA)‐induced MRI signal intensity enhancement (SIE) and contrast were monitored. Microspheres measured myocardial perfusion (MP) to verify areas of ischemia and reperfusion. Results SIEs of 86% ± 3% and 97% ± 3% in nonischemic, and 25% ± 5% and 29% ± 8% in ischemic regions were found within three minutes of onset of ischemia with Gd(ABE‐DTTA) and Gd(DTPA), respectively. For the rest of the 30 minutes of ischemia, with Gd(ABE‐DTTA) SIE of 60% ± 3% and 25% ± 5% persisted in the nonischemic and ischemic regions, respectively. With Gd(DTPA), however, SIE in the nonischemic areas decreased rapidly after the first three minutes of ischemia, while SIE in the ischemic areas increased, abolishing contrast. Thus, there was a persistent contrast with Gd(ABE‐DTTA) and a short‐lived contrast with Gd(DTPA) during ischemia. Furthermore, with Gd(ABE‐DTTA) some contrast was still visible in the early reperfusion period. Conclusion Gd(ABE‐DTTA) in an ischemia/reperfusion model induces a persistent MRI contrast between regions of normal and ischemic myocardium, and verifies reperfusion. Therefore, it can be used to detect myocardial ischemic events. J. Magn. Reson. Imaging 2005;21:536–545. © 2005 Wiley‐Liss, Inc.