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A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia
Author(s) -
Sacktor Ned,
Skolasky Richard L.,
Ernst Thomas,
Mao Xiangling,
Selnes Ola,
Pomper Martin G.,
Chang Linda,
Zhong Kai,
Shungu Dikoma C.,
Marder Karen,
Shibata Dean,
Schifitto Giovanni,
Bobo Linda,
Barker Peter B.
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20272
Subject(s) - dementia , creatine , psychomotor learning , white matter , medicine , magnetic resonance imaging , magnetic resonance spectroscopic imaging , voxel , neuropsychology , choline , nuclear medicine , cognition , radiology , psychiatry , disease
Purpose To evaluate single‐voxel proton magnetic resonance spectroscopy (SV‐MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods Twenty HIV‐positive (HIV+) individuals underwent SV‐MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV‐MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N‐acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion SV‐MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV‐MRS measures mI, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes. J. Magn. Reson. Imaging 2005;21:325–333. © 2005 Wiley‐Liss, Inc.