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Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: A feasibility study
Author(s) -
Jacobs Michael A.,
Barker Peter B.,
Argani Pedram,
Ouwerkerk Ronald,
Bhujwalla Zaver M.,
Bluemke David A.
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20239
Subject(s) - medicine , nuclear medicine , histopathology , biopsy , magnetic resonance imaging , dynamic contrast , radiology , washout , gadolinium , lesion , breast mri , breast cancer , pathology , cancer , mammography , chemistry , organic chemistry
Abstract Purpose To investigate the feasibility of combined dynamic contrast enhanced (DCE) and magnetic resonance spectroscopy (MRS) in evaluating breast lesions. Methods Nine patients with positive mammograms scheduled for either biopsy or mastectomy were examined on a 1.5‐T MR scanner. DCE was performed with administration of gadolinium‐DTPA contrast using a two‐dimensional spoiled gradient recall echo (SPGR) sequence. Proton spectroscopy (TR/TE = 2000/272 msec) was performed using PRESS single slice (10 mm). Lesion time intensity curves were classified as persistent (type 1), plateau (type 2), or washout (type 3) pattern enhancement. Choline (Cho) signal‐to‐noise ratios (SNRs) and enhancement patterns were compared between benign and malignant lesions as determined by histopathology. Results Five patients had breast carcinoma and four had benign lesions. Type 1 enhancement was found in two benign cases, type 2 enhancement in two of four benign and four of five malignant lesions, and one malignant case exhibited a type 3 pattern. Choline SNR was significantly different ( P < 0.003) between benign and malignant lesions (2.0 ± 0.3 vs. 5.7 ± 1.4; P < 0.003). Choline SNR was less than 4.0 in all of the benign lesions, including the two lesions with type 2 enhancement. Conclusion Proton MRS appears to be a promising technique for classification of breast lesions when DCE results are equivocal. A combination of DCE and MRS is feasible, and may have improved specificity compared to either modality alone. J. Magn. Reson. Imaging 2005;21:23–28. © 2004 Wiley‐Liss, Inc.