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First‐pass contrast‐enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)‐based blood pool agent
Author(s) -
Li Wei,
Tutton Sean,
Vu Anthony T.,
Pierchala Linda,
Li Belinda S.Y.,
Lewis Jerome M.,
Prasad Pottumarthi V.,
Edelman Robert R.
Publication year - 2005
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20235
Subject(s) - ferumoxytol , magnetic resonance angiography , medicine , digital subtraction angiography , magnetic resonance imaging , nuclear medicine , radiology , aorta , imaging phantom , first pass , angiography , arithmetic , mathematics
Purpose To evaluate the feasibility of first‐pass contrast‐enhanced magnetic resonance angiography (MRA) using ferumoxytol in humans. Materials and Methods First‐pass and equilibrium phase MRA were performed using ferumoxytol in one healthy volunteer and 11 patients with a fast three‐dimensional spoiled gradient recalled (SPGR) pulse sequence. The examined vessels included carotid arteries, thoracic aorta, abdominal aorta, and peripheral arteries. A dose of either 71.6 μmol Fe/kg ( n = 9), or 35.8 μmol Fe/kg ( n = 3) was used. Based on a phantom study, the agent with initial concentration of 537.2 μmol Fe/mL was diluted by either four‐fold (134.3 μmol Fe/mL) or eight‐fold (67.1 μmol Fe/mL) for first‐pass MRA. Results All subjects completed their studies without adverse events. First‐pass MRA showed selective arterial enhancement, with both arterial and venous enhancement on delayed acquisitions. Selective venous enhancement could be obtained by subtraction of arterial phase images from equilibrium phase images. The findings in ferumoxytol MRA were consistent with the results of original vascular tests. Conclusion Our preliminary experience supports the feasibility of first‐pass MRA with ferumoxytol. Satisfactory arterial enhancement during first‐pass imaging is obtained with injection of diluted contrast agent. With ferumoxytol, arteries and veins can be selectively depicted in a single exam. J. Magn. Reson. Imaging 2005;21:46–52. © 2004 Wiley‐Liss, Inc.