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Evaluation of heart perfusion in patients with acute myocardial infarction using dynamic contrast‐enhanced magnetic resonance imaging
Author(s) -
Nielsen Gitte,
FritzHansen Thomas,
Dirks Christina G.,
Jensen Gorm B.,
Larsson Henrik B.W.
Publication year - 2004
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20142
Subject(s) - medicine , perfusion , myocardial infarction , magnetic resonance imaging , perfusion scanning , multislice , infarction , radiology , cardiology , thrombolysis
Purpose To investigate the diagnostic ability of quantitative magnetic resonance imaging (MRI) heart perfusion in acute heart patients, a fast, multislice dynamic contrast‐enhanced MRI sequence was applied to patients with acute myocardial infarction. Materials and Methods Seven patients with acute transmural myocardial infarction were studied using a Turbo‐fast low angle shot (FLASH) MRI sequence to monitor the first pass of an extravascular contrast agent (CA), gadolinium diethylene triamine pentaacetic acid (Gd‐DTPA). Quantitation of perfusion, expressed as K i (mL/100 g/minute), in five slices, each having 60 sectors, provided an estimation of the severity and extent of the perfusion deficiency. Reperfusion was assessed both by noninvasive criteria and by coronary angiography (CAG). Results The K i maps clearly delineated the infarction in all patients. Thrombolytic treatment was clearly beneficial in one case, but had no effect in the two other cases. Over the time‐course of the study, normal perfusion values were not reestablished following thrombolytic treatment in all cases investigated. Conclusion This study shows that quantitative MRI perfusion values can be obtained from acutely ill patients following acute myocardial infarction. The technique provides information on both the volume and severity of affected myocardial tissue, enabling the power of treatment regimes to be assessed objectively, and this approach should aid individual patient stratification and prognosis. J. Magn. Reson. Imaging 2004;20:403–410. © 2004 Wiley‐Liss, Inc.