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Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging
Author(s) -
NagaePoetscher Lidia M.,
McMahon Michael,
Braverman Nancy,
Lawrie William T.,
Fatemi Ali,
Degaonkar Mahaveer,
Horská Alena,
Pomper Martin G.,
Chacko Vaddapuram P.,
Barker Peter B.
Publication year - 2004
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20128
Subject(s) - cerebrospinal fluid , metabolite , magnetic resonance imaging , nuclear magnetic resonance , proton magnetic resonance , magnetic resonance spectroscopic imaging , central nervous system , chemistry , pathology , medicine , nuclear medicine , radiology , biochemistry , physics
Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan‐1,2‐diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously. J. Magn. Reson. Imaging 2004;20:496–500. © 2004 Wiley‐Liss, Inc.