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Assessment of regional lung function impairment in airway obstruction and pulmonary embolic dogs with combined noncontrast electrocardiogram‐gated perfusion and gadolinium diethylenetriaminepentaacetic acid aerosol magnetic resonance images
Author(s) -
Ogasawara Nobuhiko,
Suga Kazuyoshi,
Kawakami Yasuhiko,
Yamashita Tomio,
Zaki Mohammed,
Matsunaga Naofumi
Publication year - 2004
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20087
Subject(s) - perfusion , medicine , gadolinium , lung , magnetic resonance imaging , nuclear medicine , radiology , materials science , metallurgy
Purpose To define regional function impairment in airway obstruction (AO) and pulmonary embolic (PE) dogs with a combination study of noncontrast electrocardiogram (ECG)‐gated perfusion and gadolinium diethylenetriaminepentaacetic acid (Gd‐DTPA) aerosol magnetic resonance (MR) images. Methods After acquisition of multiphase fast‐spin‐echo (FSE) MR images during cardiac cycles in 14 AO dogs and 19 PE dogs, ECG‐gated perfusion‐weighted (PW) images were obtained by subtraction between two‐phase images of the minimum lung signal intensity (SI) during systole and maximum SI during diastole. Each dog subsequently inhaled Gd‐DTPA aerosol for 20 minutes, and subtracted Gd‐DTPA aerosol images were obtained from precontrast and maximally enhanced images. ECG‐gated PW images were compared with intravenous Gd‐DTPA‐enhanced pulmonary arterial perfusion phase (PAPP) images. Results ECG‐gated PW images were consistent with Gd‐DTPA‐enhanced PAPP images in all dogs, with significant correlations in the affected‐to‐unaffected lung perfusion ratios ( P < 0.005). Gd‐DTPA aerosol images showed sufficient and uniform enhancement in the unaffected lungs. In all the AO areas, these combined images showed the matched perfusion and aerosol deposition defects. These images showed perfusion defects without aerosol deposition defects in the relatively small embolized areas, but showed the matched defects in the widely embolized areas probably due to hypoxic bronchial constriction. Conclusion The combination MR studies may be acceptable for noninvasively defining regionally impaired lung function in AO and PE. J. Magn. Reson. Imaging 2004;20:46–55. © 2004 Wiley‐Liss, Inc.