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Morphological and hemodynamic magnetic resonance assessment of early neonatal brain injury in a piglet model
Author(s) -
Munkeby Berit H.,
Lyng Kristin,
Frøen Jahn Frederik,
WintherLarssen Eldrid H.,
Rosland Jan Henrik,
Smith HansJørgen,
Saugstad Ola Didrik,
Bjørnerud Atle
Publication year - 2004
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.20084
Subject(s) - medicine , magnetic resonance imaging , perfusion , cerebral blood flow , occlusion , effective diffusion coefficient , magnetic resonance angiography , ischemia , perfusion scanning , hemodynamics , nuclear medicine , radiology , cardiology
Purpose To investigate the utility of functional and morphological magnetic resonance imaging (MRI) to assess the extent of brain injury in a hypoxia‐ischemia (HI) piglet model and further to validate that the desired ischemic injury was successfully induced. Materials and Methods MRI was performed at 1.5 T in anesthetized piglets ( N = 10, age = 12‐36 hours). Relative cerebral blood flow (rCBF), time‐to‐peak (TTP) contrast, and apparent diffusion coefficient (ADC) were estimated at different time points pre‐, during, and post‐HI. The effect following bilateral clamping of the carotid arteries was assessed by contrast‐enhanced MR angiography (MRA) and phase contrast MR angiography (PCA) ( N = 4). Results A linear correlation was observed between relative cerebral perfusion reduction and cerebral ADC during HI (r 2 = 0.85, P < 0.05). There was no correlation between rCBF reduction during 30 minutes of HI and cerebral ADC after 30 or 150 minutes of reperfusion/reoxygenation (RR). Conclusion The combination of morphological and functional (perfusion and diffusion) MRI enabled consistent assessment of both the presence and absence of complete occlusion as well as the functional significance of the occlusion. J. Magn. Reson. Imaging 2004;20:8–15. © 2004 Wiley‐Liss, Inc.