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Assessment of hepatic portal perfusion using T2* measurements of Gd‐DTPA
Author(s) -
Uematsu Hidemasa,
Yamada Hiroki,
Sadato Norihiro,
Muramoto Satoshi,
Inoue Hiroshi,
Hayashi Koji,
Yonekura Yoshiharu,
Kimura Hirohiko,
Sakuma Hajime,
Matsuda Tetsuya,
Hayashi Nobushige,
Yamamoto Kazutaka,
Ishii Yasushi
Publication year - 1998
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880080320
Subject(s) - medicine , perfusion , indocyanine green , nuclear medicine , superior mesenteric artery , blood flow , mean transit time , radiology , perfusion scanning , pathology
Recently, perfusion imaging has been of increasing interest in MRI. We applied this method for semiquantitative evaluation of hepatic parenchymal portal blood flow in patients with diffuse liver damage. Twenty patients with diffuse hepatic damage were divided according to the Child's Classification and studied. Gadolinium‐diethylenetriamine pentaacetic acid (Gd‐DTPA) was administered into the superior mesenteric artery (SMA), and a dynamic series of T2*‐weighted fast low angle shot (FLASH) images was obtained. We evaluated relative regional portal blood volume (rrPBV), mean transit time (MTT), and relative regional portal blood flow (rrPBF). The relationship between the rrPBV, rrPBF, and plasma indocyanine green retention rate test at 15 minutes (ICGR 15 ) was also evaluated in 12 patients. Both rrPBF and rrPBV are significantly decreased in Child B & C patients compared with Child A patients. On the other hand, the MTT is significantly prolonged in Child B & C patients compared with Child A patients. Significant correlations were also noted between rrPBV and ICGR 15 and between rrPBF and ICGR 15 . By means of selective catheterization into the SMA, we were able to estimate rrPBV, rrPBF, and MTT. This method may play a clinical role for assessment of regional portal perfusion in various diseases with diffuse liver damage.