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Magnetization transfer fast imaging of implanted glioma in the rat brain at 4.7 T: Interpretation using a binary spin‐bath model
Author(s) -
Quesson Bruno,
Bouzier AnneKarine,
Thiaudiere Eric,
Delalande Christophe,
Merle Michel,
Canioni Paul
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070621
Subject(s) - magnetization transfer , nuclear magnetic resonance , glioma , nuclear medicine , basal ganglia , irradiation , magnetic resonance imaging , chemistry , materials science , pathology , medicine , physics , central nervous system , radiology , cancer research , nuclear physics
C6 glioma cells were implanted in the left caudate nucleus of the rat brain. Histologic studies confirmed the presence of neoplastic tissue surrounded by a thin edematous region. Proton magnetization transfer contrast (MTC) fast imaging, using continuous wave off‐resonance irradiation, was performed in vivo at 4.7 T with the rapid acquisition with relaxation enhancement (RARE) sequence. The observed MTC allowed very clear distinction of the tumoral region, in which magnetization transfer (MT) ratios were lower than in healthy tissues. Contrasts were analyzed as a function of the offset frequency and the amplitude of the radiofrequency (RF) irradiation. The contrast was higher between the contralateral basal ganglia and the tumor and lower between the tumor and the temporal lobe. Modeling of MT in the three brain regions was performed using a system including free water and a pool of protons with restricted motions. The rate of exchange between the two pools exhibited a decreasing hierarchy from the basal ganglia to the tumor. T2 B values for the immobile protons ranged from 9.3 μsec in the basal ganglia to 7.5 μsec for the glioma. The acquisition conditions leading to the highest contrasts between the tumor and the healthy tissues correspond to 3,000 Hz offset frequency and 300 to 700 Hz RF irradiation amplitude.