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Paradoxic uptake of Gd‐EOB‐DTPA by hepatocellular carcinoma in mice: Quantitative image analysis
Author(s) -
Fujita Makoto,
Yamamoto Reiko,
Takahashi Masaya,
Tsuji Takashi,
Yamanaka Tsuyoshi,
Miyazawa Tomoaki,
FritzZieroth Bernhard,
Terada Nobuyuki,
Kuroda Chikazumi
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070426
Subject(s) - hepatocellular carcinoma , medicine , lesion , gadolinium , pathology , nuclear medicine , chemistry , organic chemistry
To determine whether paradoxic uptake of gadoliniumethoxybenzyl‐diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA) occurs only with highly differentiated hepatocellular carcinomas, quantitative image analysis was performed in 37 mice with 133 hepatocellular carcinomas. The results of lesion/liver signal intensity measurement and relative enhancement calculation indicate that paradoxic positive enhancement occurs independently of cellular differentiation.