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Use of an intravascular T1 contrast agent to improve MR cine myocardial‐blood pool definition in man
Author(s) -
Stillman Arthur E.,
Wilke Norbert,
JeroschHerold Michael
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070425
Subject(s) - contrast (vision) , intensity (physics) , medicine , segmentation , magnetic resonance imaging , nuclear medicine , biomedical engineering , radiology , computer science , artificial intelligence , physics , optics
The feasibility of improving myocardial/blood pool contrast in MR cine images through use of an intravascular contrast agent (Ferumoxtran, Advanced Magnetics, Inc., Cambridge, MA) was tested in four subjects. The contrast‐to‐noise ratio (CNR) demonstrated a trend toward improvement in the short axis and improved significantly in the long axis cine by an average of 128% (P < .05). Image intensity gradients at the myocardial/blood pool interface increased significantly in both the short and long axis (P < .01). It is expected that larger image intensity gradients at the endocardial border should improve the capabilities of automated segmentation algorithms, reducing the uncertainty and need for manual editing.