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Xenon effects on regional cerebral blood flow assessed by 15 O‐H 2 O positron emission tomography: Implications for hyperpolarized xenon MRI
Author(s) -
Liotti Mario,
Martin Charles C.,
Gao JiaHong,
Roby John W.,
Mayberg Helen S.,
Zamarripa Frank,
Jerabek Paul A.,
Fox Peter T.
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070424
Subject(s) - cerebral blood flow , positron emission tomography , xenon , nuclear medicine , inhalation , medicine , blood flow , visual cortex , positron , stimulation , ventilation (architecture) , anesthesia , chemistry , neuroscience , physics , psychology , radiology , organic chemistry , thermodynamics , quantum mechanics , electron
Abstract Subjective and physiologic effects of 33% inhaled Xe were measured with 15 O‐water positron emission tomography (PET) in 3 subjects at rest and during visual stimulation. The procedure was well tolerated. Robust functional activations of the visual cortex were obtained after xenon (Xe) inhalation as well as air breathing. However, Xe inhalation was followed by smaller size, but significant decreases of regional cerebral blood flow (rCBF) in visual cortex relative to the air‐breathing baseline, both during visual stimulation and at rest. No such decreases were found in other sensory or motor regions.