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Contrast‐to‐noise ratio in functional MRI of relative cerebral blood volume with sprodiamide injection
Author(s) -
Lev Michael H.,
Kulke Sarah F.,
Sorensen A. Gregory,
Boxerman Jerry L.,
Brady Thomas J.,
Rosen Bruce R.,
Buchbinder Brad R.,
Weisskoff Robert M.
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070312
Subject(s) - magnetic resonance imaging , nuclear medicine , white matter , medicine , cerebral blood volume , contrast to noise ratio , radiology , image quality , artificial intelligence , computer science , image (mathematics)
The purpose of this study was to investigate the dependence of contrast‐to‐noise ratio (CNR) on the dose and rate of sprodiamide injection in magnetic resonance relative cerebral blood volume (rCBV) imaging. rCBV maps for 35 normal volunteers were constructed from dynamic MR image sets acquired with echo‐planar spin‐echo imaging after intravenous injection of sprodiamide. Doses of .1, .2, and .3 mmol/kg, at rates of 2 ml/second and 5 ml/second, were tested. CNRs and blood/volume ratios of gray to white matter were computed. CNR depended on dose ( P < .0001) but was independent of injection rate ( P < .69). rCBV ratios of gray to white matter were dose independent ( P < .38) and rate independent ( P < .97). The dependence of CNR on dose, but not injection rate, has practical implications in optimal protocol design. The independence of gray/white ratios supports the theory underlying the generation of rCBV maps.