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Evaluation of peri‐infarcted hypoperfusion with T2*‐weighted dynamic MRI
Author(s) -
Tsuchida Chika,
Yamada Hiroki,
Maeda Masayuki,
Sadato Norihiro,
Matsuda Tsuyoshi,
Kawamura Yasutaka,
Hayashi Nobushige,
Yamamoto Kazutaka,
Yonekura Yoshiharu,
Ishii Yasushi
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070311
Subject(s) - medicine , perfusion , nuclear medicine , cerebral blood flow , perfusion scanning , infarction , cerebral blood volume , magnetic resonance imaging , cerebral perfusion pressure , blood flow , radiology , myocardial infarction
The purpose of this study was to evaluate cerebral perfusion with T2*‐weighted dynamic MRI in the area around the infarcted core. We examined seven patients with subacute cerebral infarction. After bolus injection of gadopentetate dimeglumine, a series of gradient‐echo images were recorded in a selected slice. From these images, concentration‐time curves were created on a region‐of‐interest (ROI) basis around infarction for calculating relative regional cerebral blood volume (rrCBV). Brain perfusion single photon emission computed tomography (SPECT) study also was performed with intravenous injection of 123 I‐labeled N ‐isopropyl‐p‐iodoamphetamine ( 123 I‐IMP). All patients showed prolonged signal decrease in the area around the infarcted core. ROI analysis showed significantly increased rrCBV compared to the normal side ( P < .01, paired t test). The 123 I‐IMP SPECT study showed that these areas had decreased cerebral blood flow. These findings suggest compensatory vascular dilatation due to decreased perfusion pressure. T2*‐weighted dynamic MRI is a useful method for detecting compensatory vasodilatation of ischemic insult in the peri‐infarcted area.