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Delineation of liver necrosis using double contrast‐enhanced MRI
Author(s) -
Dupas Benoǐt,
BachGansmo Tore,
Nomballais Marie Françoise,
Meflah Kahled
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070304
Subject(s) - necrosis , gadolinium , dysprosium , medicine , contrast (vision) , magnetic resonance imaging , lesion , pulse (music) , nuclear medicine , pathology , radiology , chemistry , inorganic chemistry , organic chemistry , artificial intelligence , detector , computer science , electrical engineering , engineering
Abstract The purpose of this study was to demonstrate the potential usefulness of the combination of gadolinium and dysprosium to enhance the difference between normal and necrotic liver tissue. Small regions of acute necrosis were induced by injecting 200–300 μl of 95% alcohol into the liver of 26 rats. MRI was performed 24 hours after necrosis induction, before and immediately after injection of one or both contrast agents. Using a mixed T1/T2‐weighted sequence, the signal intensity (SI) of the normal liver was reduced by 70%, whereas the necrotic regions had more than a 50% increase in SI after double contrast. The region that was enhanced corresponded largely with the region of necrosis as observed postmortem. The lesion size, when identified, was largely underestimated using either of the agents alone, albeit using the common pulse sequences. The double contrast effect of simultaneous administration of gadolinium and dysprosium allows accurate delineation of liver necrosis.