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A reproducible repositioning method for serial magnetic resonance imaging studies of the brain in treatment trials for multiple sclerosis
Author(s) -
Gallagher H. L.,
Macmanus D. G.,
Webb S. L.,
Miller D. H.
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070232
Subject(s) - multiple sclerosis , medicine , magnetic resonance imaging , radiology , lesion , nuclear medicine , clinical trial , pathology , psychiatry
Serial MRI is an important measure of disease progression in evaluating the treatment of multiple sclerosis (MS). Accurate comparisons of scans for lesion activity and lesion volume require precise repositioning of patients. A simple, reproducible repositioning method is described. In a multicenter treatment trial of MS using β‐interferon‐1b, this method has been successful, with only 1.1% of scans being rejected because of poor repositioning.