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MR assessment of iodinated contrast‐medium‐induced nephropathy in rats using ultrasmall particles of iron oxide
Author(s) -
Laissy Jean Pierre,
Benderbous Soraya,
Idée Jean Marc,
Chillon Sylvie,
Beaufils Hélène,
SchoumanClaeys Elisabeth
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070125
Subject(s) - medicine , iodinated contrast , nephropathy , nuclear medicine , contrast medium , diatrizoate , kidney , medulla , isotonic , saline , renal cortex , in vivo , urology , radiology , endocrinology , computed tomography , diabetes mellitus , microbiology and biotechnology , biology
Abstract The purpose of this study was to determine the diagnostic value of ultrasmall particles of iron oxide (USPIO)‐enhanced MR imaging at different concentrations to evaluate experimental nephropathy. This study was conducted in 23 uninephrectomized rats using a model of iodinated contrast media‐induced renal failure. Eleven rats received selective intra‐arterial renal administration of diatrizoate (370 mg I/m1) and were compared to two control groups, including five animals injected with isotonic saline and seven noninjected animals. MR imaging was performed 28 hours after the procedure, including T1‐ and T2‐weighted images before and after intravenous administration of successively 5 μmol Fe/kg and 60 μmol/kg of USPIO. Results were interpreted qualitatively and quantitatively with respect to pathologic data, and differences were studied statistically. The maximal signal intensity decrease was noted in normal kidneys in cortex (−65 ± 4%) and medulla (−84 ± 5%) on T2‐weighted images after injection of 60 μmol/kg of USPIO. At this dose, diseased kidneys displayed less signal intensity decrease than normal kidneys on T2‐weighted images ( p = .05). Moreover, qualitative analysis showed that the highest sensitivity and specificity to diagnose kidney involvement were obtained with T2‐weighted MR images (75% and 91%, respectively) when 60 μmol/kg of USPIO were used ( p < .01). USPIO should be useful for in vivo evaluation of the severity of experimentally induced iodinated contrast media renal impairment in animals.