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Physiologic measurements by contrast‐enhanced MR imaging: Expectations and limitations
Author(s) -
Roberts Timothy P. L.
Publication year - 1997
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.1880070112
Subject(s) - magnetic resonance imaging , contrast (vision) , perfusion , biomedical engineering , dynamic contrast , computer science , blood volume , medicine , vascular permeability , permeability (electromagnetism) , radiology , chemistry , pathology , artificial intelligence , biochemistry , membrane
Contrast‐enhanced magnetic resonance imaging (MRI) offers the opportunity to quantitatively assess physiologic properties of tissue, such as perfusion, blood volume, and capillary permeability. Use of such quantitation potentially allows tissues to be characterized in terms of pathophysiology and to be monitored over time, during the course of therapeutic intervention. The degree to which such quantitation is applicable relies heavily on simplified model descriptions of the tissue space and assumptions relating the signal intensity observed to the contrast agent concentration. This article presents a perspective on the use of quantitative contrast‐enhanced MRI, analysis of the accuracy of derived physiologic parameters, and recommendations for pulse sequence choice.